
Cravatt Reagent
CAS No. 1438416-21-7
Cravatt Reagent( MJN110 )
Catalog No. M20397 CAS No. 1438416-21-7
Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
Purity : >98% (HPLC)






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Biological Information
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Product NameCravatt Reagent
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NoteResearch use only, not for human use.
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Brief DescriptionCravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
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DescriptionCravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
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In VitroMJN110 (0.01-1000 nM; 4 hours) has the primary serine hydrolase target, hMAGL, with an IC50 of ~1 nM and 10- and 100-fold selectivity windows over ABHD6 and LYPLA1/2, respectively. Western Blot Analysis Cell Line:Human-derived PC3 cells Concentration:0.01, 0.1, 1, 10, 100, 1000 nM Incubation Time:4 hours Result:HMAGL acted as the primary serine hydrolase target with an IC50 of ~1 nM.
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In VivoMJN110 (i.p.; 0.0818 mg/kg; twice daily for 5.5 days) reverses chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. The respective ED50 value (95% confidence limits) is 0.430 (0.233-0.793) mg/kg. Animal Model:Male C57BL/6J mice ranged from 18 to 35 g Dosage:0.0818 mg/kg Administration:I.p.; twice daily for 5.5 days Result:Reversed CCI-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner.
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SynonymsMJN110
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PathwayMetabolic Enzyme/Protease
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TargetLipase
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RecptorMAGL
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Research Area——
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Indication——
Chemical Information
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CAS Number1438416-21-7
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Formula Weight462.3
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Molecular FormulaC22H21Cl2N3O4?
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (540.74 mM)
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SMILESClc1ccc(cc1)C(N1CCN(CC1)C(=O)ON1C(=O)CCC1=O)c1ccc(Cl)cc1
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Chemical Name4-[bis(4-chlorophenyl)methyl]-1-piperazinecarboxylic acid 25-dioxo-1-pyrrolidinyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wilkerson J L Niphakis M J Grim T W et al. The selective monoacylglycerol lipase inhibitor MJN110 produces opioid sparing effects in a mouse neuropathic pain model[J]. Journal of Pharmacology and Experimental Therapeutics 2016:jpet.115.229971.
molnova catalog



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