Cravatt Reagent

CAS No. 1438416-21-7

Cravatt Reagent( MJN110 )

Catalog No. M20397 CAS No. 1438416-21-7

Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 39 In Stock
10MG 71 In Stock
25MG 160 In Stock
50MG 259 In Stock
100MG 467 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Cravatt Reagent
  • Note
    Research use only, not for human use.
  • Brief Description
    Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
  • Description
    Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
  • In Vitro
    MJN110 (0.01-1000 nM; 4 hours) has the primary serine hydrolase target, hMAGL, with an IC50 of ~1 nM and 10- and 100-fold selectivity windows over ABHD6 and LYPLA1/2, respectively. Western Blot Analysis Cell Line:Human-derived PC3 cells Concentration:0.01, 0.1, 1, 10, 100, 1000 nM Incubation Time:4 hours Result:HMAGL acted as the primary serine hydrolase target with an IC50 of ~1 nM.
  • In Vivo
    MJN110 (i.p.; 0.0818 mg/kg; twice daily for 5.5 days) reverses chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. The respective ED50 value (95% confidence limits) is 0.430 (0.233-0.793) mg/kg. Animal Model:Male C57BL/6J mice ranged from 18 to 35 g Dosage:0.0818 mg/kg Administration:I.p.; twice daily for 5.5 days Result:Reversed CCI-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner.
  • Synonyms
    MJN110
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Lipase
  • Recptor
    MAGL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1438416-21-7
  • Formula Weight
    462.3
  • Molecular Formula
    C22H21Cl2N3O4?
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (540.74 mM)
  • SMILES
    Clc1ccc(cc1)C(N1CCN(CC1)C(=O)ON1C(=O)CCC1=O)c1ccc(Cl)cc1
  • Chemical Name
    4-[bis(4-chlorophenyl)methyl]-1-piperazinecarboxylic acid 25-dioxo-1-pyrrolidinyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wilkerson J L Niphakis M J Grim T W et al. The selective monoacylglycerol lipase inhibitor MJN110 produces opioid sparing effects in a mouse neuropathic pain model[J]. Journal of Pharmacology and Experimental Therapeutics 2016:jpet.115.229971.
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