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Cravatt Reagent

CAS No. 1438416-21-7

Cravatt Reagent ( MJN110 )

Catalog No. M20397 CAS No. 1438416-21-7

Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cravatt Reagent
  • Note
    Research use only not for human use.
  • Brief Description
    Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
  • Description
    Cravatt Reagent is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
  • Synonyms
    MJN110
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Lipase
  • Recptor
    MAGL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1438416-21-7
  • Formula Weight
    462.3
  • Molecular Formula
    C22H21Cl2N3O4?
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Clc1ccc(cc1)C(N1CCN(CC1)C(=O)ON1C(=O)CCC1=O)c1ccc(Cl)cc1
  • Chemical Name
    4-[bis(4-chlorophenyl)methyl]-1-piperazinecarboxylic acid 25-dioxo-1-pyrrolidinyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wilkerson J L Niphakis M J Grim T W et al. The selective monoacylglycerol lipase inhibitor MJN110 produces opioid sparing effects in a mouse neuropathic pain model[J]. Journal of Pharmacology and Experimental Therapeutics 2016:jpet.115.229971.
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